Abouzid, Khaled

khaled.abouzid@pharma.asu.edu.eg

Department of Pharmaceutical Chemistry - Pharmacy
Interests: Anticancer drug discovery, design and synthesis, Antimicrobial,
Internal ID: rp12178
  • 2,885 Scopus Citations
  • 592 PubMed Citations

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Full Name
Abouzid, Khaled
 
 
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Biography
Dr. Khaled Abouzid is a Professor of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain Shams University, Prominent Scholar in Drug Discovery, Co-founding Director of Center of Drug Discovery and Development Research ASU He was nominated as the Acting Dean of the Faculty of Pharmacy, University of Sadat City from 8-2018 to 8-2022. He is currently a member of national pharmaceutical chemistry promotion committee
Dr. Abouzid’s research is directed towards drug discovery of bioactive small molecules with special emphasis on cannabinoids, targeted anticancer, anti-inflammatory, anti-viral anti-microbial agents and enzyme inhibitors. He has published over 150 research papers, two books and filed 14 patents in medicinal chemistry. He has Scopus H index of 28. He has supervised over 100 Master and PhD students in 7 universities. Dr Abouzid has research collaborations with German, British, Swedish, Canadian and US universities. He has also organized and presided over 34 international symposia and conferences.
Dr. Abouzid obtained his B.Sc. degree in Pharmaceutical Sciences from Cairo University in 1985, and his PhD. joint degree in Organic Chemistry from the Faculty of Pharmacy, Cairo University and School of Pharmacy University of Connecticut, USA.
Dr. Abouzid started his career in 1995 as a lecturer of Organic Chemistry at Cairo University, Faculty of Pharmacy. In 2001, he moved to the Department of Pharmaceutical Chemistry, Ain Shams University, and was promoted to Associate Professor in 2003. He did postdoctoral work with Professor Jochen Lehman of the Friedrich-Schiller-Universität Jena, Germany.

Publications

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Issue DateTitleAuthor(s)
115-Feb-2022Discovery of a benzimidazole-based dual FLT3/TrKA inhibitor targeting acute myeloid leukemiaDokla, Eman ; Abdel-Aziz, Amal Kamal; Milik, Sandra N.; McPhillie, Martin J.; Minucci, Saverio; Khaled A M Abouzid 
21-Dec-2021Indolin-2-one derivatives as selective Aurora B kinase inhibitors targeting breast cancerDokla, Eman ; Abdel-Aziz, Amal Kamal; Milik, Sandra N.; Mahmoud, Amr H.; Saadeldin, Mona Kamal; McPhillie, Martin J.; Minucci, Saverio; Khaled A M Abouzid 
31-Aug-2020Penicillin binding protein 2a: An overview and a medicinal chemistry perspectiveShalaby, Menna-Allah W; Dokla, Eman ; Serya, Rabah ; Khaled A M Abouzid 
49-Apr-2020Targeting YAP Degradation by a Novel 1,2,4-Oxadiazole Derivative via Restoration of the Function of the Hippo PathwayDokla, Eman ; Fang, Chun Sheng; Chu, Po Chen; Chang, Chih Shiang; Chen, Ching S.; Khaled A M Abouzid 
515-Jan-2020Development of benzimidazole-based derivatives as antimicrobial agents and their synergistic effect with colistin against gram-negative bacteriaAbutaleb, Nader S; Milik, Sandra N; Li, Daoyi; El-Baz, Karim; Shalaby, Menna-Allah W; Al-Karaki, Rawan; Nasr, Maha ; Klein, Christian D; Seleem, Mohamed N; Dokla, Eman ; Khaled A M Abouzid 
6Dec-2019Towards discovery of novel scaffold with potent antiangiogenic activity; design, synthesis of pyridazine based compounds, impact of hinge interaction, and accessibility of their bioactive conformation on VEGFR-2 activitiesJaballah, Maiy Y; Serya, Rabah ; Saad, Nasser; Khojah, Sohair M; Ahmed, Marawan; Barakat, Khaled; Khaled A M Abouzid 
715-Nov-20191,2,4-Oxadiazole derivatives targeting EGFR and c-Met degradation in TKI resistant NSCLCDokla, Eman ; Fang, Chun Sheng; Chen, Ching S.; Abouzid, Khaled 
82019Identification of novel pyrazole and benzimidazole based derivatives as PBP2a inhibitors: Design, synthesis, and biological evaluationShalaby, Menna-Allah; Dokla, Eman ; Serya, Rabah ; Abouzid, Khaled 
92019Design, synthesis and molecular docking of novel pyrazolo[1,5-a][1,3,5]triazine derivatives as CDK2 inhibitorsOudah, Khulood H; Najm, Mazin A A; Samir, Nermin; Serya, Rabah ; Khaled A M Abouzid 
102019Design, synthesis, biological evaluation and dynamics simulation of indazole derivatives with antiangiogenic and antiproliferative anticancer activityElsayed, Nevine M Y; Serya, Rabah ; Tolba, Mai ; Ahmed, Marawan; Barakat, Khaled; Abou El Ella, Dalal ; Khaled A M Abouzid 
11Dec-2018Identification of new pyrrolo[2,3-d]pyrimidines as potent VEGFR-2 tyrosine kinase inhibitors: Design, synthesis, biological evaluation and molecular modelingAdel, Mai; Serya, Rabah ; Lasheen, Deena S. ; Khaled A M Abouzid 
1215-Jul-2018Surmounting the resistance against EGFR inhibitors through the development of thieno[2,3-d]pyrimidine-based dual EGFR/HER2 inhibitorsMilik, Sandra N; Abdel-Aziz, Amal Kamal; Serya, Rabah ; Minucci, Saverio; Lasheen, Deena S. ; Khaled A M Abouzid 
1325-May-2018Alkoxyphenylthiazoles with broad-spectrum activity against multidrug-resistant gram-positive bacterial pathogensElAwamy, Moustafa; Mohammad, Haroon; Hussien, Abdelrahman; Abutaleb, Nader S; Hagras, Mohamed; Serya, Rabah ; Taher, Azza T; Seleem, Mohamed N; Mayhoub, Abdelrahman S; Khaled A M Abouzid 
1415-Dec-2017How to train your inhibitor: Design strategies to overcome resistance to Epidermal Growth Factor Receptor inhibitorsMilik, Sandra N; Lasheen, Deena S; Serya, Rabah ; Abouzid, Khaled A M; Khaled A M Abouzid 
1530-Jan-2017Click and Release: SO2 Prodrugs with Tunable Release RatesSerya, Rabah ; Khaled A.M.abouzid; Deena S.Lasheen; Xingyue Ji; Binghe Wang; Khaled A M Abouzid 
1615-Apr-2016Discovery of Potent VEGFR-2 Inhibitors based on Furopyrimidine and Thienopyrimidne Scaffolds as Cancer Targeting AgentsAziz, Marwa A; Serya, Rabah A T; Lasheen, Deena S. ; Abdel-Aziz, Amal Kamal ; Mansour, Ahmed M; Ahmed Esmat ; Singab A. ; Khaled A M Abouzid 
17Nov-2015Development of Potent Adenosine Monophosphate Activated Protein Kinase (AMPK) ActivatorsFang, Chun-Sheng; Lai, Po-Ting; Kulp, Samuel K; Serya, Rabah ; Ismail, Nasser S M; Chen, Ching-Shih; Dokla, Eman ; Khaled A M Abouzid 
182015Synthesis and in vitro antiproliferative activity of novel pyrazolo[3,4-d]pyrimidine derivativesAbdou, Nermin S.; Serya, Rabah ; Esmat, Ahmed ; Tolba, Mai F.; Ismail, Nasser S. M.; Khaled A M Abouzid 
19Dec-2014Design, synthesis, 3D pharmacophore, QSAR, and docking studies of carboxylic acid derivatives as Histone Deacetylase inhibitors and cytotoxic agentsAbdel-Atty, Mona M; Farag, Nahla A; Kassab, Shaymaa E; Serya, Rabah ; Khaled A M Abouzid 
20Jun-2014Molecular design and synthesis of 1,4-disubstituted piperazines as α(1)-adrenergic receptor blockersHussein, Mohammed M; Serya, Rabah ; Abdel Naby, Rana M; Al-Abd, Ahmed M; Saleh, Dalia O; El-Eraky, Wafaa I; Khaled A M Abouzid ; Abou El Ella, Dalal