Abouzid, Khaled

khaled.abouzid@pharma.asu.edu.eg

Department of Pharmaceutical Chemistry - Pharmacy
Interests: Anticancer drug discovery, design and synthesis, Antimicrobial,
Internal ID: rp12178
  • 2,885 Scopus Citations
  • 592 PubMed Citations

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Abouzid, Khaled
 
 
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Biography
Dr. Khaled Abouzid is a Professor of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain Shams University, Prominent Scholar in Drug Discovery, Co-founding Director of Center of Drug Discovery and Development Research ASU He was nominated as the Acting Dean of the Faculty of Pharmacy, University of Sadat City from 8-2018 to 8-2022. He is currently a member of national pharmaceutical chemistry promotion committee
Dr. Abouzid’s research is directed towards drug discovery of bioactive small molecules with special emphasis on cannabinoids, targeted anticancer, anti-inflammatory, anti-viral anti-microbial agents and enzyme inhibitors. He has published over 150 research papers, two books and filed 14 patents in medicinal chemistry. He has Scopus H index of 28. He has supervised over 100 Master and PhD students in 7 universities. Dr Abouzid has research collaborations with German, British, Swedish, Canadian and US universities. He has also organized and presided over 34 international symposia and conferences.
Dr. Abouzid obtained his B.Sc. degree in Pharmaceutical Sciences from Cairo University in 1985, and his PhD. joint degree in Organic Chemistry from the Faculty of Pharmacy, Cairo University and School of Pharmacy University of Connecticut, USA.
Dr. Abouzid started his career in 1995 as a lecturer of Organic Chemistry at Cairo University, Faculty of Pharmacy. In 2001, he moved to the Department of Pharmaceutical Chemistry, Ain Shams University, and was promoted to Associate Professor in 2003. He did postdoctoral work with Professor Jochen Lehman of the Friedrich-Schiller-Universität Jena, Germany.

Publications

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Issue DateTitleAuthor(s)
1Dec-2022Design, synthesis, and biological evaluation of new thieno[2,3-d] pyrimidine derivatives as targeted therapy for PI3K with molecular modelling studyElmenier, Fatma M; Lasheen, Deena ; Abouzid, Khaled 
2Dec-2022Molecular design, synthesis and biological evaluation of novel 1,2,5-trisubstituted benzimidazole derivatives as cytotoxic agents endowed with ABCB1 inhibitory action to overcome multidrug resistance in cancer cellsAbdelhafiz, Abeer H A; Serya, Rabah A T; Lasheen, Deena S. ; Wang, Nessa; Sobeh, Mansour; Wink, Michael; Abouzid, Khaled 
3Dec-2022Discovery of EMD37, a 1,2,4-oxadiazole derivative, as a novel endoplasmic reticulum stress inducer with potent anticancer activityAbdel-Aziz, Amal Kamal ; Khaled A M Abouzid ; Minucci, Saverio; Dokla, Eman 
4Oct-2022New fluorinated diarylureas linked to pyrrolo[2,3-d]pyrimidine scaffold as VEGFR-2 inhibitors: Molecular docking and biological evaluationAdel, Mai; Abouzid, Khaled 
510-Apr-2022Towards Selective Binding to the GLUT5 Transporter: Synthesis, Molecular Dynamics and In Vitro Evaluation of Novel C-3-Modified 2,5-Anhydro-D-mannitol AnalogsRana, Natasha; Aziz, Marwa A; Oraby, Ahmed K; Wuest, Melinda; Dufour, Jennifer; Abouzid, Khaled ; Wuest, Frank; West, F G
68-Mar-2022Identification of novel furo[2,3-d]pyrimidine based chalcones as potent anti-breast cancer agents: synthesis, in vitro and in vivo biological evaluationMansour, Mai A; Oraby, Mamdouh A; Muhammad, Zeinab A; Lasheen, Deena ; Gaber, Hatem M; Khaled A M Abouzid 
7Mar-2022Identification of a promising hit from a new series of pyrazolo[1,5-a]pyrimidine based compounds as a potential anticancer agent with potent CDK1 inhibitory and pro-apoptotic properties through a multistep in vitro assessmentElgiushy, Hossam R; Mohamed, Sameh H; Sawaf, Hussein; Hassan, Zeinab; Abou-Taleb, Nageh A; El-Labbad, Eman M; Hassan, Ashraf S; Abouzid, Khaled A M; Abouzid, Khaled ; Ali Taha, Heba
8Feb-2022Structure-based design and synthesis of conformationally constrained derivatives of methyl-piperidinopyrazole (MPP) with estrogen receptor (ER) antagonist activityRagab, Mahmoud A; Elagawany, Mohamed; Daabees, Hoda; Ahmed, Al-Shaimaa F; Awad, Eman M; Billon, Cyrielle; Elgendy, Bahaa; Abouzid, Khaled ; Kassab, Shaymaa E
92022Insights into the design of inhibitors of the EGFR family with anticancer activity overcoming resistance: A case of optimizing thieno[2,3-d]pyrimidine-based EGFR inhibitorsMilik, SN; Abdel-Aziz, AK; El-Hendawy, MM; El-Gogary, RI; Saadeldin, MK; Minucci, S; Klein, CD; Abouzid, Khaled 
102022Tackling Microbial Resistance with Isatin-Decorated Thiazole Derivatives: Design, Synthesis, and in vitro Evaluation of Antimicrobial and Antibiofilm ActivityKassab, Refaie M; Al-Hussain, Sami A; Elleboudy, Nooran ; Albohy, Amgad; Zaki, Magdi E A; Abouzid, Khaled ; Muhammad, Zeinab A
112022Hands-on synthetic approaches and biological activities of anthranilic acid derivatives: A mini-reviewNasr, Tamer; Aboshanab, Ahmed; Abouzid, Khaled ; Zaghary, Wafaa
12Dec-2021Molecular design, synthesis and in vitro biological evaluation of thienopyrimidine-hydroxamic acids as chimeric kinase HDAC inhibitors: a challenging approach to combat cancerAbdel-Atty, Mona M; Farag, Nahla A; Serya, Rabah A T; Abouzid, Khaled ; Mowafy, Samar
131-Sep-2021Antimicrobial and Cytotoxicity Evaluation of New 3-Allyl-2-iminothiazolidin-4-onesHammad, Shaymaa G.; El-Gazzar, Marwa G.; Abdel-Halim, Mohammad; Elrazaz, Eman ; El-Hossary, Ebaa M.; Khaled A M Abouzid 
14Sep-2021Synthesis, in vitro biological investigation, and molecular dynamics simulations of thiazolopyrimidine based compounds as corticotrophin releasing factor receptor-1 antagonistsElgiushy, Hossam R; Abou-Taleb, Nageh A; Holz, George G; Chepurny, Oleg G; Pirmettis, Ioannis; Kakabakos, Sotirios; Karageorgos, Vlasios; Liapakis, George; Albohy, Amgad; Abouzid, Khaled ; Hammad, Sherif F
15Aug-2021Discovery of potent thieno[2,3-d]pyrimidine VEGFR-2 inhibitors: Design, synthesis and enzyme inhibitory evaluation supported by molecular dynamics simulationsElrazaz, Eman ; Serya, Rabah A T; Ismail, Nasser S M; Albohy, Amgad; Abou El Ella, Dalal ; Khaled A M Abouzid 
16Apr-2021Structure- and Ligand-Based in silico Studies towards the Repurposing of Marine Bioactive Compounds to Target SARS-CoV-2Fayed, Marwa A A; El-Behairy, Mohammed Farrag; Abdallah, Inas A; Abdel-Bar, Hend Mohamed; Elimam, Hanan; Mostafa, Ahmed; Moatasim, Yassmin; Abouzid, Khaled ; Elshaier, Yaseen A M M
172021Medicinal Chemistry Strategies Towards SO2 Donors as Research Tools and Potential TherapeuticsEl-Labbad, Eman M; Ji, Xingyue; Abouzid, Khaled ; Wang, Binghe
182021Lipid polymer hybrid nanocarriers as a combinatory platform for different anti-SARS-CoV-2 drugs supported by computational studiesAbdel-Bar, Hend Mohamed; Abdallah, Inas A.; Fayed, Marwa A. A.; Moatasim, Yassmin; Mostafa, Ahmed; El-Behairy, Mohammed Farrag; Elimam, Hanan; Elshaier, Yaseen A. M. M.; Abouzid, Khaled 
192021Synthesis, In Silico and In Vitro Antimicrobial Evaluation of Cyanoketene S,N-Acetals and Their Pyrazoles Against Staphylococcus Aureus DNA Gyrase EnzymeAli, Shimaa; H.I. Faraag, Ahmed; Elgiushy, Hossam; Said, Taghred; askar, ahmed; Hassan, ashraf; Abouzid, Khaled ; Fouad, Sherif
20Dec-2020Design, synthesis and biological evaluation of a new thieno[2,3-d]pyrimidine-based urea derivative with potential antitumor activity against tamoxifen sensitive and resistant breast cancer cell linesSharaky, Marwa; Kamel, Marwa; Aziz, Marwa A; Omran, Mervat; Rageh, Monira M; Abouzid, Khaled ; Shouman, Samia A